Dear Ms. Pavek
            Our observations indicate this is not an unusual
reaction......in cases of low water intake.  You may find that the
discomfort is a result of a "concentration" of an irritating
substance/compound.
                           Sincerely.  Brooks Bradley

Liz Pavek wrote:

>  The only reaction I have experienced on high doses of MSM is a
> burning on urination.  This disappears immediately when the dosage is
> reduced.  Has anyone else noticed something like this? Liz