Hmmm.. I wonder if a few drops of DMSO in the mix might enhance penetration. After all, that is what DMSO is spectacular at. Lola H.
On Fri, Nov 2, 2012 at 3:31 PM, mgperrault <mgperra...@aol.com> wrote: > Melly > > I follow you, noting you had the promise of good results, if only you had > not forgotten to continue treatment. Thats good. > > Its perhaps worth clarifying that the actives in tea tree (especially > terpinen-4-ol) are quickly evaporated and the wax was thought to slow down > the evaporation and allow a continual application which seems to be > important. We might think that something was absorbed when a large part of > it simply evaporated. As long as you have some pungent wax visible, some of > the actives are perfusing out, but an application of volatile oils may have > simply evaporated instead of being absorbed. The barrier function of skin > is so good that many of the volatiles in essential oils like tea tree > barely make it through. So slow diffusion through the nail and skin might > be the answer for the people that didnt have the same promising results you > have. > > Im not convinced that jojoba can penetrate the nail which is like > plastic. But maybe you are right. Imagine a bottle made of nail material, > you could probably store oil in it....seems like. The terpines in tea > tree seem like they could get through easier than the oil, if only they > didnt evaporate first! > > > > On 11/2/2012 10:57 AM, Melly Bag wrote: > > MGP, > > All i can say is that when i applied the combo of tea tree oil and jojoba > oil, i saw it disappear, so it was absorbed, after a few minutes. My nails > had improved. Had i not forgotten to continue treatment, i am sure it > would have healed nicely. > > I stopped using nail polish as most in the market now have toulene. > Terpentenes are so drying, if the nails are dry all the more it would crack > if you use terp. > > I tried coconut oil without any other oil as it is touted as antifungal > and no dice. > > Another thing, it is easier to penetrate the skin than the nail. As i > originally said jojoba is very thin, it could penetrate the nail. > > In my experience, if i make cream with beeswax, the wax stays visible on > top of the skin while vco is absorbed by skin. > > Melly > > ======================================================================== > > How about tea tree? > > tea tree contains several terpenoids of which terpinen-4-ol shows a > favorable skin penetration. One study starts out saying this; > > Since its introduction, transdermal drug delivery has promised much but, > in some respects has still to deliver on that initial promise, due to > inherent limitations imposed by the percutaneous route. The greatest > obstacle for transdermal delivery is the barrier property of the stratum > corneum. Many approaches have been employed to breach the skin barrier, of > which, the most widely used one is that of chemical penetration enhancers. > Of the penetration enhancers, terpenes are arguably the most highly > advanced and proven category and are classified as generally regarded as > safe (GRAS) by the Food and Drug Administration > > Terpenes are included in the list of Generally Recognized As Safe (GRAS) > substances and have low irritancy potential. Their mechanism of > percutaneous permeation enhancement involves increasing the solubility of > drugs in skin lipids, disruption of lipid/protein organization and/or > extraction of skin micro constituents that are responsible for maintenance > of barrier status. Hence, they appear to offer great promise for use in > transdermal formulations. This article is aimed at reviewing the mechanisms > responsible for percutaneous permeation enhancement activity of terpenes, > which shall foster their rational use in transdermal formulations. > > The thing about tea tree however is that it will likely evaporate before > significant penetration occurs. Use of an occlusion method may therefor > increase its therapeutic action. Perhaps jojoba or coconut would retard the > evaporation and perhaps increase the penetration by other means. It is said > that jojoba is more like a wax than an oil. An ointment made with bees wax > might increase the occlusion and reduce evaporation rate even further. > Coconut has anti fungal properties and so a combination of coconut, bees > wax, oregano and tea tree might be good. > > Another study on transdermal drug delivery found that of lemon grass oil, > eucalyptus, menthol and clove, that clove oil had the highest penetration > enhancement. Since clove is also antibiotic, it could be useful. Perhaps > clove, or any combination of clove, oregano, tea tree incorporated into a > bees wax base with the viscosity controlled by coconut and or jojoba oil > could make a useful ointment. This is what I do and it seems effective for > many skin problems although I havent tried it on nail infections > > There are medicated nail lacquers that are said to be effective with > minimal side effects. One could just go with it, or try to make their own > by using tee trea, clove, oregano and some kind of lacquer. The constant > exposure and diffusion of the actives is the benefit of the lacquer, so > this could have some value.... > > >
