hughman1 wrote:

> To add my two cents worth,
> When my wife was diagnosed with Crohn`s disease, the cultures of her gut
> revealed Clostridium Dificile.
> Hugh

  Hi Hugh,

 Thats a nasty one. Lets bring the others up to speed on it.

 Some hospital patients taking antibiotics (or home patients) may develop a
severe inflamation of the colon called "pseudomembranous colitis" (PMC). It
is characterized be high fever, severe abdominal pain and diarrhea.
 PMC is caused by "Clostridium difficile" (its that clostridium again), a
bacterium that normally occure only in very low numbers in the colon because
it competes poorly with the normal flora bacteria. Now, antibiotics that
inhibit the normal flora may allow Cl. difficile to multiply in large
numbers and produce two toxins. (now a large unbalance in the flora). One
toxin causes the diarrhea, which washes out many of the desirable residual
normal bacteria from the intestine and colon. Both toxins kill the
epithelial cells that line the colon wall, causing blood plasma to leak into
the colon and clot.
 The clots consist of fibrin, dead epithelial cells and white blood cells;
they appear as tough, whitist-yellow plaques of pseudo-membrane (false
membrane) on the colon wall.
 The death rate is about 10 to 30%. Fortunately PMC can be effectively
treated by using vancomycin or metronidazole to stop the growth of Cl.
difficile. They will not kill it but do allow the normal flora to catch up
and effect balance again, if you stay off the antibiotics.


Bless you          Bob Lee
--
oozing on the muggy shore of the gulf coast
  [email protected]



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