Hi James, You have possed some VERY interesting and vital questions, but I can only answer as to my "gut feeling."
I weigh in at 190 pounds and I take one ounce morning and evening. If there were an alert I would up that to eight ounces twice daily, and would institute Brooks Bradley's protocol with 80 % CS , 20 % Dmso, and 2% MSM in an artist air brush. If I were to go so far as the IV technique then I would consider the ultra voilet radiation of about 100 cc of blood and reinject it. That has proved very effective in many diseases and it acts within minutes. There are some D.O.'s that do that. "Ole Bob"