Dear Marshall,
You said: <<It is possible that mice and rats don't have a bbb, or don't have a very good one? For the purpose of keeping toxic metals out of the brain, the human would need this since they live over 50 years, but a rat which dies much sooner, would likely not accumulate enough metal in the brain during it's lifetime to make it need such an efficient one.>> An article on thr BBB of mice: New mdr1a Knockout Mouse Model Facilitates Drug-Resistance Studies Toxicity Studies Several investigators in the United States are already using the mdr1a knockout in their research. Dr. Jean Lud Cadet at the Addiction Research Center in Baltimore uses the mdr1a model to examine the long-term toxic effects of methamphetamine on the brain, with potential implications for amphetamine-using humans. To study the causes of methamphetamine toxicity, researchers use the mdr1a knockout mouse, which is vulnerable to CNS toxicity, and a wild-type control mouse that is protected by the blood-brain barrier from the toxic effects of amphetamines. Dr. Cadet, a psychiatrist and neurologist for the National Institute on Drug Abuse, decided to use the mdr1a knockout mouse after he read that it contained virtually no mdr1a P-glycoprotein that is vital to the protective function of the blood-brain barrier, yet the mice are otherwise healthy, viable, and physiologically the same as wild-type cousins.... http://www.taconic.com/newsltrs/nov96/nov96b.htm -- The silver-list is a moderated forum for discussion of colloidal silver. Instructions for unsubscribing may be found at: http://silverlist.org To post, address your message to: silver-list@eskimo.com Silver-list archive: http://escribe.com/health/thesilverlist/index.html List maintainer: Mike Devour <mdev...@eskimo.com>
