This is pretty long, but very interesting.  I believe the PS at the end is by 
Brooks Bradley concerning the addition of CS to the protocol.

BY DR. KENNETH BURTON 
The devastation caused by the bite of the Brown Recluse spider can be stopped 
in its tracks and reversed, even at  advanced stages of its degenerative 
effects. 

The Recluse bite can cause a prolonged and expensive trail of suffering and 
disability to its victims. The frequency of bites to humans has increased at an 
alarming rate, as the spider moves indoors and into our garments, shoes and 
bedding. Treatment cost now run into the millions of dollars per year and are 
rising rapidly as incidences increase.While some spiders inject little venom, 
others may be expected to create serious management problems with resultant 
extensive tissue loss, pain. disability and chronic deterioration. 

The etiology is the powerful, vasoconstricting properties of the venom, as the 
mechanism of necrotic arachnidism, which causes the smail arteries to spasm 
with resultant loss of blood supply to the bite area. This sets up a cycle of 
ulceration and tissue loss through ischemia and gangrene. Systemic medication 
alone is unable to penetrate the lesion because of the barrier zone produced by 
the spastic occlusion of the arteries. 

However...a nitroglycerin patch can penetrate through the skin, into the 
interstitial fluid and into the capillaries, rapidly dilating the vessels. This 
is evidenced by the quick onset of a nitroglycerin headache as circulation into 
the occluded area is re-established from the edges inward. The pathologic 
process ceases and healing begins. When a nitro patch is administered early, as 
in the first 48 hours, no lesion ever develops!  Delay treatment three to four 
weeks and a 5 cm ulcer will develop, requiring three months of treatment with 
the nitroglycerin patches. Even with delayed treatment, however, the 
degenerative process is reversed. The body heals itself. There is no need for 
surgery with its debilitating effects, potential complications and severe 
scarring. 

The patch is cut to cover only the effected area, right up to and extending 
just over the edge of involvement. In the case of a youngchild, the patch 
should be cut down to cover the smallest area possible, with more frequent 
removal and reapplication necessary. Pictures of the recluse bites treated with 
these patches provide examples of some responses. 

With few exceptions, regardless of the site of the bite or the age and health 
of the patient, the patch has stopped the progress of the tissue loss, thus 
allowing the area to begin recovery, usually without scarring and with only 
slightly darker pigmentation. 

  
*3 wks. old untreated lesion near wrist *After 7 weeks treatment on Nitro 0.2 
patch - completely healed - no scar 

Exceptions include a patient with a very old ulcer (10 months), one whose bite 
was at the posterior knee joint and who was not diligent in keeping the patch 
on in this difficult location, and a patient whose auto immunity was 
compromised by HIV. I have found the Deponit Nitroglycerinpatch to be the most 
effective patch of the several types tried because the nitroglycerin is 
dispersed throughout the matrix, the dosage is easily controlled, and the patch 
is very flexible (important for joint areas).  Nitroglycerin spray was also 
used, and found to be very effective when applied to a bite of no more than 
several days age. Under no circumstances will oral nitroglycerin be 
appropriate. With blood flow re-established to the bite site, systemic 
antibiotics are effective and patients are prescribed Ciproflaxin for the first 
five to seven days to counteract bacteria - possibly delivered by the spider's 
fangs - and to prevent potential bone involvement. Patients should be 
instructed that in the event of a headache the patch should be removed for up 
to one hour and then replaced. 
I have been using this procedure in my private practice since 1989 with amazing 
and conclusive results. In instances where I see the bite so early on as to be 
unable to positively identify as a Brown Recluse bite (most times the victim 
does not see the spider, or if they do the response is to pulverize it, thus 
allowing no method of identification other than an examination of the affected 
area), I will initiate treatment with the nitroglycerin patches as a 
precaution. There is no danger from its use on other bites, but to delay 
treatment from uncertainty only allows further degradation and necessitates a 
prolonged treatment period. The patch will also help scorpion and other bites 
anyway. Exception: Do not use on snake bite
.
 Dear Ivan,  Our researcher reports he has employed CS as an 
adjunct to the nitroglycerin protocol....simply by applying 10 to 15 ppm 
strength CS (diluted 5% by volume with DMSO) with an eye-dropper, directly 
on the nitroglycerin patch. 
Although only anecdotal in nature, his observation is that both the speed of 
healing and suppression of opportunistic pathogens is measureably increased. 
Best Regards, Brooks.