Hi, Frank! The Herxheimer reaction gives some evidence that something germicidal has made it into the bloodstream. This could be put on a quantitative basis by a bioassay procedure.
A more compelling demonstration would be occurrence of a Herxheimer reaction following the transfusion of blood to recipient who had not ingested EIS, from a donor who had ingested EIS. This, of course, would not prove the silver was still ionized. But it would prove that a germicidal agent existed in the bloodstream. Best regards, Matthew