snip >>> Examination of islet and beta-cell integrity after exposure to GS4, by trypan blue exclusion, indicated that concentrations of GS4 that stimulated insulin secretion also caused increased uptake of dye. Two gymnemic acid-enriched fractions of GS4, obtained by size exclusion and silica gel chromatography, also caused increases in insulin secretion concomitant with increased trypan blue uptake. These results confirm the stimulatory effects of G. sylvestre on insulin release, but indicate that GS4 acts by increasing cell permeability, rather than by stimulating exocytosis by regulated pathways.> > > > > > > And what this says is that gymnema increases the release of insulin from the pancreas, and the mechanism is increasing cell permeability and making it leaky to the insulin comes out more readily. This is very different that increasing insulin sensitivity (responsiveness) at the cell level in the peripheral tissues. Releasing more insulin actuallly worsens hyperinsulinemia, which in turn may lower blood sugar but at the expense of insulinemic damage throughout the system.
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