Source: www.centocor.com

"The ER-TIMI 19 trial is a multicenter, open-label study involving 
20 geographically diverse emergency medical systems in North America.
The primary endpoint is time saved with pre-hospital initiation of
RETAVASE in fibrinolytic-eligible patients with ST elevation on a 
12-lead ECG, transmitted to hospital-based medical control
physicians.

The study found that for patients receiving pre-hospital treatment
with RETAVASE, the median time from EMS arrival to the first RETAVASE
bolus was 31 minutes, compared with 64 minutes for those given
RETAVASE at the hospital. 
The rapid pre-hospital administration of RETAVASE worked to stabilize

heart-attack patients, with 29% already showing a greater than 50%
resolution of their elevated ST segments, an electrocardiogram
indicator of heart health, by the time they arrived at the emergency
room. Complete ST-segment resolution (>70%) was achieved in 15
percent of pre-hospital-treated patients by emergency department
arrival and 54 percent by 90 minutes after the first bolus of
RETAVASE. To date, twelve (5.4%) deaths and two (0.9%) intracranial
hemorrhages have occurred, rates that are consistent with other
fibrinolytic trials."

Nuance N-A
- Le 12 derivees arrive 10 min plus vite en milieu urbain
- Et il arrive XX min encore plus vite en milieu Semi-urbain et rural
- Les EMS ne se substituent a aucun departement d'hospital 
- Un peu comme les Traumas Systems, il existe (pas partout) des
systèmnes d'orientation des urgences cardiologiques (Angio 24/24)

Charles Brault EMT-P


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