On the PC Dragon Naturally Speaking is the one most vendors base on. I have a 
 mac at home, and have tried iListen, it was horrible, but it was a more 
basic version. Macs  have several "speakable item" controls built-in. They 
ironically usually require you to press a key to signal the machine to listen 
to the 
voice command, which kind of defeats the purpose...  The keystroke thing can 
be programmed away, but it's an annoyance. You can supposedly use iListen to 
map keywords to every keystroke shortcut in the computer and all it's software 
apps.  I just didn't have much luck "teaching" it my voice. A quality  headset 
microphone is supposed to help. I explored using this setup for quad patients 
to control a video editing program. It works on paper, but not too good yet in 
practice, the apps you're trying to control may not be as complicated.

Depending on your friend's level of functioning, the head-tracking software 
used by flight simmers works very well for say C-5 or better. You or a helper 
must stick a small self-adhesive dot decal on  the bridge of your  eyeglasses 
or your forehead, (comes with a set plus refills) then the thing tracks your 
head posture just like a mouse. Add a puffer switch for mouse click and you're 
in business.

In Illinois, some places to look at for adaptation equipment would include 
the world-renowned Rehabilitation Institute of Chicago, and  try the state of 
Illinois web page, department of Human Services, for their Assistive technology 
Clearinghouse program. They have samples of every device out there and can 
make recommendations.

Best of luck with it.
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