You're not going to be able to serialize Python class instances in JSON:
json strings are simple object literals limited to basic Javascript types.
Pickle does some pretty heavy lifting to serialize and reconstitute class
instances.

Easiest way to store JSON in the database is to limit the type of data you
store in JSON strings to straightforward objects that only use primitive JS
types, and then serialize back and forth to Python dictionaries. That's what
libraries like SimpleJSON or cJSON do. Using Sqlalchemy, you can then store
those JSON strings in database VARCHARS, TEXT and so on fields.

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