Are you looking for the `or_`

from sqlalchemy.sql import and_, or_

abcd = or_((table.col_1 == a, table.col_2 == b),
  (table.col_1 == b, table.col_2 == c),
  )
session.query(table).filter(**abcd).all()

that should generate something like 

   SELECT * FROM table WHERE (col_1 == a and col_2 == b) OR (col_1 == c and 
col_2 == d);

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