yes the tuple construct provides this:

https://docs.sqlalchemy.org/en/13/core/sqlelement.html?highlight=tuple#sqlalchemy.sql.expression.tuple_

>>> from sqlalchemy import select, column, tuple_
>>> stmt = select([column('q')]).where(tuple_(column('x'), column('y')) == 
>>> tuple_(3, 4))
>>> print(stmt)
SELECT q
WHERE (x, y) = (:param_1, :param_2)


however, tuples are not supported on all backends and it's safer to use AND:

>>> from sqlalchemy import and_
>>> stmt = select([column('q')]).where(and_(column('x') == 3, column('y') == 4))
>>> print(stmt)
SELECT q
WHERE x = :x_1 AND y = :y_1

>From a Python perspective, there's no real reason to use one or the other, as 
>either one can be generated programmatically.

the tuple_ construct is provided mostly to support IN expressions against 
composite values, for equality it's not strictly necessary.

On Fri, Oct 9, 2020, at 8:51 AM, Massimiliano della Rovere wrote:
> Greetings,
> is it possible using sqlalchemy core to obtain the following code:
> 
> [...]
> WHERE (column1, column2) = (value1, value2)
> 
> this is useful to use multi columnar indexes having column1 and column2 in 
> the two leftmost position and in later position columns that I put in the 
> SELECT section. 
> 

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