> cache_mem 4048 MB

This is not the size of the cache in total, it is only the size of the
cache in memory. Do you have enough memory to allow for 4048 MB cache
mem, and the mem for the OS, and the mem for the squid process and the
mem for the index of the cache files on disk?

I have not seen any cache_dir lines in your config, so i assume you use
the default of 100 MB.

Normaly you should use a big disk cache size (cache_dir) and a small mem
cache size (cache_mem) not bigger than 8 MB.

Hermann

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