Comment #11 on issue 2571 by asmeurer: Regression in Integral.subs http://code.google.com/p/sympy/issues/detail?id=2571
OK, to be clear, I agree that we should not replace integration/differentiation variables with subs (or anything else where only a Symbol make sense).
I'm not sure if subs() currently satisfies this, but it may if old is a Symbol.
Probably not because it will have varying luck replacing things depending on the structure of the expression.
This discussion is all very related to my discussion on the mailing list on how to extend subs to be able to turn on and off different rules.
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