I found the problem,

Thanks Chris for the advice, that 'pointer' is in the profiles.ini
"Path=C:\Mail\Profile"

I found the answer here http://kb.mozillazine.org/Moving_your_profile_folder

Firefox, Thunderbird and SeaMonkey 2

If some add-ons don't work after moving your profile, open the profile
folder and delete these files (they will be regenerated): [1]

    * compreg.dat
    * extensions.cache
    * extensions.ini
    * extensions.rdf
    * pluginreg.dat  (not applicable to T-Bird)

So there's the answer.

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