This concerns low vision impairments not blindness which involves ARIA & 
screenreaders (which I remember a previous topic covered) and I'm not at 
that stage yet so I really can't speak on it (I have one-- Zoomtext but it 
got crippled by a Windows update).  I am not a certified "expert" on the 
subject-- there's plenty of references onlline (including Microsoft)-- but 
have plenty of first hand experience.

This covers some of the vision impairments, accessibility solutions and how 
they may impact content display and how TW works with them.

TLDR:
Most wiki creators fortunatley won't have to worry too much because there's 
OS & browser accessibilty features, 3rd party browser extensions and full 
fledged accessibilty programs to handle the task for you.  TW seems to work 
with Windows & Firefox's accessibility features (from user experienve with 
Windows 150% DPI & High Contrast Black system theme).  What the wiki 
creator or dev needs to do is avoid things that could disable such 
accessibilty features/programs such as "!important" on css (reason why: 
"Why CSS !important Should Be Used Carefully" section at 
https://www.developeracademy.io/blog/css-important-rule-use-correctly/).

Don't override the default underlining on links, its a well known attribute 
of links, even if the color of links is overridden.  TW shows the 
underlining when links are mouse over.

Instead of relying exclusively on colors, use labels, icons for buttons 
etc.  Use tooltips to identify such, provide instructions.

A point was made that users set their own styling in their browser not just 
because of visual impairment but to make web content more "readable" to 
their eyesight/preference.

The full details:

Vision impairment is actually a wider subject than complete blindness-- 
there is more low vison sufferers (17% users with mild vision impairment) 
than blind people (9% with severe)-- it's the stage where vision exists but 
its restricted in some way-- that could make their vision ineffective in 
certian situations.  Like having a leg that works except it can't bend at 
the knee.

Colorblindness is a common example-- someone else is going to broach that 
subject...

Color blindness will prevent people from potentionally fully seeing or 
understanding any color coding you may use with themes or things such as 
color coded text, buttons, borders, etc.

Low vision impairment is the other. It has several aspects:

Blurry vision/unable to read small text- user will use accessiblity 
features like larger monitor set at lower screen resoltion or zoom (Windows 
screen scaling/DPI scaling, browser zoom features, font size settings)

Results will be like with mobile device screens, wide screen layouts may 
get broken up into several lines or overlapped.  Responsive layouts may end 
up with content in very narrow & tall containers.

TW seems to handle Windows & Firefox's zoom abilities, font settings well.

Loss of contrast in vision:
and
Unable to view light color backgrounds (common to people suffering from 
vision loss due to diabeties):

Current low contrast themes for normal sighted people (lighter colors 
instead of dark (like text) on white background or grey (instead of white 
or bright light colors) on dark backgrounds).  Where these are designed for 
ease of eye strain for normal sighted people but they can be hard for 
someone with loss of contrast vision to see-- the text will seem to fade 
into the background.

Windows has user set themes for background colors and for user adjusted 
contrast or preset high contrast system themes (high contrast - black on 
white background) and "high contrast black" - white on black background for 
maximum contrast between foreground element colors and the background.  
Firefox applies the Windows system theme to its chrome/UI and webpages.

What this entails-- at least for high contrast black (I don't know about 
standard high contrast)-- is that all css/html colors (backgrounds, text, 
border colors) are disabled and replaced by white on black (including 
default html colors such as links).

Web browsers also have settings/custom global stylesheets, extensions/add 
ons that do the same thing-- override css/html color settings, fonts and 
sizes, even images.

TW applies Windows & Firefox's High Contrast Black theme well, except for: 

- - the toolbar icons-- with Vanilla theme, they nearly disappear (faded 
grey) except whrn mouse over, them they appear white.

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