Darwin's famous illness is frequently retrospectively diagnosed as
psychosomatic (a lovely catch-all term for an illness that eludes obvious
explanation), and/or he has been labelled a hypochondriac. But some
Cardiff University researchers contend that his symptoms are closely
consistent with lactose intolerance:

http://www.abc.net.au/science/news/ancient/AncientRepublish_1353681.htm

Charles Darwin had lactose intolerance
ABC Science Online
Tuesday, 26 April 2005
Charles Darwin was lactose intolerant, researchers deduce, adding a fresh
twist to the mystery of what caused his 40-year-long illness.

This would explain the bouts of vomiting, stomach pains, severe tiredness,
skin problems and depression Darwin suffered, symptoms a new report says
improved when he stopped eating milk and cream.

His family also suffered in a similar way, suggesting a genetic component,
researchers led by Professor Anthony Campbell from Cardiff University
reports in the current issue of the Postgraduate Medical Journal.

Darwin wrote to his friends about how his symptoms would sometimes last
for weeks, with some bouts so bad that he couldn't work on his theories of
evolution and natural selection.

For example, the young naturalist had heart palpitations and chest pains
before the Beagle set sail from Plymouth on what would be a landmark
voyage to South America and the Galapagos Islands.

But he didn't tell anyone about his ailments because he was frightened it
might prevent him from sailing.

Researchers attributed these and other symptoms to everything from heart
disease, arsenic poisoning, a pigeon allergy, and a severe reaction to the
death of his mother.

Misdiagnosis
But researchers were not convinced these were the answer to Darwin's
mystery illness, which 20 doctors, including his father, failed to treat.

His symptoms came and went but did not seem to be triggered by stress,
affecting his gut, heart, brain, muscles, joints and immune system.

While these were evidence for lactose intolerance, they could also
indicate other conditions.

Perhaps the most telling evidence was Darwin's own description.

He wrote in his health diary how symptoms generally came on within two to
three hours of eating, the time it takes for lactose to reach the large
intestine.

Lactose intolerance is caused by the lack of the enzyme lactase, which
would normally break down sugars found in milk products to molecules the
body finds easier to digest.

So Darwin's body would have struggled to deal with his rich diet, which
family recipes show included desserts with custard and cream, and white
sauces with vegetables.

The only time Darwin got better was by chance, after a drastic change to
his diet that meant he coudn't eat custard or milk.

He also responded well to hydrotherapy treatment, which involved drinking
lots of water. This would have cut his milk intake, the researchers
propose.

Genetic component
Many people in Darwin's family, including his children, had similar
symptoms, which the researchers say is consistent with an inherited loss
of the enzyme lactase.

"What we need now is a blood spot, a hair or even a swab off a document
from some skin, so that we can carry out the DNA test [for the inherited
form of lactase loss]," the researchers write.

While the researchers say the evidence points to an inherited condition,
they say his symptoms may also have been exacerbated by a gut infection
with the protozoan that causes Chagas' disease.

Evolutionary importance
Humans are unusual among mammals as they keep producing the enzyme lactose
after they are weaned onto solid food.

But Darwin did not explain the evolutionary advantage of this in either of
his two books On The Origin of Species or The Descent of Man, the
researchers say.


Allen Esterson
Former lecturer, Science Department
Southwark College, London
[EMAIL PROTECTED]

http://www.human-nature.com/esterson/index.html
http://www.butterfliesandwheels.com/articleprint.php?num=10
http://www.butterfliesandwheels.com/articleprint.php?num=57
http://www.butterfliesandwheels.com/articleprint.php?num=58
http://www.srmhp.org/0202/review-01.html


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