----- Original Message -----
From: "Linda Bartoshuk"
To: "Ron Blue" <[EMAIL PROTECTED]>
Sent: Wednesday, September 12, 2001 2:51 PM
Subject: Re: Fw: PROP tasting
> Dear Ron,
> PROP is a medication used to treat an overactive thyroid. As a med, it is
> consumed in amounts like 200 mg per day. Taste testing does not involve
> swallowing and even if it did the amounts are way below 200 mg. We use a
daily
> dose of PROP as our standard for making the argument that even if a
subject
> disobeyed our instructions and drank all stimuli available in a session,
she/he
> would not exceed a daily dose. IRBs know this if they consult an
> endocrinologist. PROP is consumed even by newborn babies with thyroid
> problems. The more serious problem is that some individuals develope
symptoms
> from taking PROP clinically. These symptoms do not develope immediately
> (certainly not from one day's dose) and we ask potential subjects about
their
> medical histories to eliminate any that might react to PROP.
>
> I don't know how many medications are chemically from families of
compounds
> "reasonably anticipated to be a human carcinogin."
>
> Any investigators planning to use PROP can find out about it medical use
from
> endocrinology texts.
> Linda Bartoshuk
>
> Ron Blue wrote:
>
> > ----- Original Message -----
> > From: "Steven Specht" <[EMAIL PROTECTED]>
> > To: "tips" <[EMAIL PROTECTED]>; <[EMAIL PROTECTED]>
> > Sent: Monday, September 10, 2001 6:48 PM
> > Subject: PROP tasting
> >
> > > During the process of determining from where to obtain
> > > 6-n-propylthiouracil (PROP) for use in taste experiments to
investigate
> > > the role of genetic components in contrast effects, I came across a
> > > report written by folks at the National Institute of Environmental
> > > Health and Safety (NIEHS of NIH) which lists PROP as "Reasonably
> > > anticipated to be a human carcinogen". This substance has been used
> > > regularly (and recently) by a number of investigators in human
testing.
> > > Does anyone know why this is getting through IRB? I'm not sure of the
> > > date of the report (but it appears to be post-1989).
> > >
> > > --
> > >
> >
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
> > >
> > > Steven M. Specht, Ph.D.
> > > Associate Professor of Psychology
> > > Psychology Department
> > > Utica College of Syracuse University
> > > 1600 Burrstone Rd.
> > > Utica, NY 13502
> > > (315) 792-3171
> > >
> > > "To teach is to learn twice". - Joseph Joubert (1754-1824)
> > >
> > >
> > >
>
