I have been experiencing identical issues since around mid-January or so
(though my latency sometimes reaches 3000/4000+ ms during these times).
I am running a freshly installed and fully updated version of Ubuntu
18.04 Desktop.  For the first couple of months after installing 18.04 I
had none of these issues whatsoever, they seemed to materialize during a
period when I was doing a lot of heavy software development which used a
great deal of system resources (multiple VMs). Originally the
workstation was wired directly to my router, but even after purchasing a
wireless USB adapter I am still experiencing the issue.

I typically use remote viewing software to work on the affected
workstation (from another laptop in my home), and once I begin to notice
moderate sluggishness in the response time of the system I can typically
run "sudo systemctl restart network-manager" and I will usually not
begin to experience the issue again until several hours later,
typically.  If I go too long without running that command the full 10-15
minute period of extreme latency will set in.  It doesn't return fully
to "normal" response times after that high period, but it is far lower
than the most extreme patches.

I hesitate to say that the issue is similar to other bug reports because
of the "dropping of the connection" aspects of those.  The connection
never fully dies in this case, but just experiences periods of latency
related unusability.

Any logs or further info available upon request.

-- 
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Touch seeded packages, which is subscribed to network-manager in Ubuntu.
https://bugs.launchpad.net/bugs/1804280

Title:
  intermittent periods of packet loss and high latency

Status in linux package in Ubuntu:
  Confirmed
Status in network-manager package in Ubuntu:
  Confirmed

Bug description:
  Intermittently and unpredictably, ping response times and packet loss
  will spike to unusable levels.  Normal ping times are about .25 ms for
  other hosts on the local network, with essentially no packet loss.
  During the problematic periods (usually lasting 2-10 minutes), packet
  loss jumps to about 50% and ping response times on the packets that
  aren't dropped jump to between 250 and 750 ms.

  This behavior started when I upgraded from Kubuntu 16.04 to Kubuntu
  18.04.  Changing which host on the network I test this with has no
  effect (and during this, those other hosts are able to use the network
  without any problem).  Replacing the cable changes nothing.  Using a
  different Ethernet interface changes nothing.  Replacing the switch
  changes nothing.  This is almost certainly not a hardware problem.

  There is a chance that using wireless instead of Ethernet would fix
  the issue, but I have been avoiding that since the wired connection is
  much faster when Kubuntu is not malfunctioning.

  ProblemType: Bug
  DistroRelease: Ubuntu 18.04
  Package: network-manager 1.10.6-2ubuntu1.1
  ProcVersionSignature: Ubuntu 4.15.0-39.42-generic 4.15.18
  Uname: Linux 4.15.0-39-generic x86_64
  ApportVersion: 2.20.9-0ubuntu7.5
  Architecture: amd64
  CurrentDesktop: KDE
  Date: Tue Nov 20 12:48:05 2018
  IfupdownConfig:
   # interfaces(5) file used by ifup(8) and ifdown(8)
   auto lo
   iface lo inet loopback
  InstallationDate: Installed on 2016-12-09 (711 days ago)
  InstallationMedia: Kubuntu 16.04 LTS "Xenial Xerus" - Release amd64 
(20160420.1)
  IpRoute:
   default via [removed] dev enp0s31f6 proto dhcp metric 100
   169.254.0.0/16 dev enp0s31f6 scope link metric 1000
   [removed]/24 dev enp0s31f6 proto kernel scope link src [removed] metric 100
  NetworkManager.state:
   [main]
   NetworkingEnabled=true
   WirelessEnabled=true
   WWANEnabled=true
  SourcePackage: network-manager
  UpgradeStatus: Upgraded to bionic on 2018-08-19 (92 days ago)
  nmcli-dev:
   DEVICE             TYPE      STATE         DBUS-PATH                         
         CONNECTION          CON-UUID                              CON-PATH
   enp0s31f6          ethernet  connected     
/org/freedesktop/NetworkManager/Devices/2  Wired connection 1  
2e0d0ce3-8ee2-3c06-815d-eb9a42873b3b  
/org/freedesktop/NetworkManager/ActiveConnection/5
   [removed]  bt        disconnected  /org/freedesktop/NetworkManager/Devices/5 
 --                  --                                    --
   wlp3s0             wifi      disconnected  
/org/freedesktop/NetworkManager/Devices/4  --                  --               
                     --
   lo                 loopback  unmanaged     
/org/freedesktop/NetworkManager/Devices/1  --                  --               
                     --
  nmcli-nm:
   RUNNING  VERSION  STATE      STARTUP  CONNECTIVITY  NETWORKING  WIFI-HW  
WIFI     WWAN-HW  WWAN
   running  1.10.6   connected  started  full          enabled     enabled  
enabled  enabled  enabled
  --- 
  ProblemType: Bug
  ApportVersion: 2.20.9-0ubuntu7.5
  Architecture: amd64
  AudioDevicesInUse:
   USER        PID ACCESS COMMAND
   /dev/snd/controlC0:  dan        2053 F.... pulseaudio
   /dev/snd/pcmC1D0c:   dan        2053 F...m pulseaudio
   /dev/snd/controlC1:  dan        2053 F.... pulseaudio
  CurrentDesktop: KDE
  DistroRelease: Ubuntu 18.04
  HibernationDevice: RESUME=UUID=4eadd7fe-e046-471d-b0ee-f1c85365411e
  IfupdownConfig:
   # interfaces(5) file used by ifup(8) and ifdown(8)
   auto lo
   iface lo inet loopback
  InstallationDate: Installed on 2016-12-09 (712 days ago)
  InstallationMedia: Kubuntu 16.04 LTS "Xenial Xerus" - Release amd64 
(20160420.1)
  IpRoute:
   default via 192.168.4.1 dev enp0s31f6 proto dhcp metric 100 
   169.254.0.0/16 dev enp0s31f6 scope link metric 1000 
   192.168.4.0/24 dev enp0s31f6 proto kernel scope link src 192.168.4.42 metric 
100
  MachineType: Dell Inc. Precision Tower 3420
  NetworkManager.state:
   [main]
   NetworkingEnabled=true
   WirelessEnabled=true
   WWANEnabled=true
  Package: network-manager 1.10.6-2ubuntu1.1
  PackageArchitecture: amd64
  ProcFB: 0 inteldrmfb
  ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-4.15.0-39-generic 
root=UUID=89b1b98c-8c19-4200-966b-190a0ca44440 ro quiet splash vt.handoff=1
  ProcVersionSignature: Ubuntu 4.15.0-39.42-generic 4.15.18
  RelatedPackageVersions:
   linux-restricted-modules-4.15.0-39-generic N/A
   linux-backports-modules-4.15.0-39-generic  N/A
   linux-firmware                             1.173.2
  Tags:  bionic
  Uname: Linux 4.15.0-39-generic x86_64
  UpgradeStatus: Upgraded to bionic on 2018-08-19 (93 days ago)
  UserGroups: adm cdrom dip lpadmin plugdev sambashare sudo vboxusers
  _MarkForUpload: True
  dmi.bios.date: 08/17/2018
  dmi.bios.vendor: Dell Inc.
  dmi.bios.version: 2.11.1
  dmi.board.name: 08K0X7
  dmi.board.vendor: Dell Inc.
  dmi.board.version: A00
  dmi.chassis.type: 3
  dmi.chassis.vendor: Dell Inc.
  dmi.modalias: 
dmi:bvnDellInc.:bvr2.11.1:bd08/17/2018:svnDellInc.:pnPrecisionTower3420:pvr:rvnDellInc.:rn08K0X7:rvrA00:cvnDellInc.:ct3:cvr:
  dmi.product.family: Precision
  dmi.product.name: Precision Tower 3420
  dmi.sys.vendor: Dell Inc.
  nmcli-dev:
   DEVICE             TYPE      STATE         DBUS-PATH                         
         CONNECTION          CON-UUID                              CON-PATH     
                                      
   enp0s31f6          ethernet  connected     
/org/freedesktop/NetworkManager/Devices/2  Wired connection 1  
2e0d0ce3-8ee2-3c06-815d-eb9a42873b3b  
/org/freedesktop/NetworkManager/ActiveConnection/5 
   B0:48:1A:D8:81:FB  bt        disconnected  
/org/freedesktop/NetworkManager/Devices/5  --                  --               
                     --                                                 
   wlp3s0             wifi      disconnected  
/org/freedesktop/NetworkManager/Devices/4  --                  --               
                     --                                                 
   lo                 loopback  unmanaged     
/org/freedesktop/NetworkManager/Devices/1  --                  --               
                     --
  nmcli-nm:
   RUNNING  VERSION  STATE      STARTUP  CONNECTIVITY  NETWORKING  WIFI-HW  
WIFI     WWAN-HW  WWAN    
   running  1.10.6   connected  started  full          enabled     enabled  
enabled  enabled  enabled

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