Twisted is a general library for networking -- you can use it to write both servers and clients, usable together in the same process or separately. "Distributed system" is a broad name that covers a lot of different things, so there are several different possible approaches. Here are some general resources you may find useful:
A general introduction to writing software with Twisted: http://krondo.com/?page_id=1327 AMP, a simple bidirectional message protocol: http://twistedmatrix.com/documents/current/core/howto/amp.html http://twistedmatrix.com/documents/current/api/twisted.protocols.amp.html Can you describe more specifically what you're interested in writing?
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