Have you changed the settings on these programs? I don't have mixxx installed (studio doesn't install it by default) but I can run a youtube video and then start Musescore and hit play and it will play along with the video. Musescore seems to come with IO set to portaudio with the API set to alsa and the device set to "default" ( the default alsa device is PulseAudio unless you have changed that). I am not sure what mixxx would do with that.
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