Christopher, I've installed the kernel linux- image-4.5.0-040500rc1-generic_4.5.0-040500rc1.201601241731_amd64.deb on the links you described and the issue does not happen any more.
Thanks for the info. ** Tags added: kernel-fixed-upstream kernel-fixed-upstream-4.5-rc1 -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1538710 Title: USB devices do not work after booting with mouse plugged on Dell desktop To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/linux/+bug/1538710/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs