Had this same issue and the workaround in #35 solved it:

Steps:
#open /etc/default/grub for editing as root
sudo gedit /etc/default/grub

# find the line GRUB_CMDLINE_LINUX="" and add the options "i8042.nomux=1 
i8042.reset"
# example:
GRUB_CMDLINE_LINUX="i8042.nomux=1 i8042.reset"

#update grub:
sudo update-grub

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https://bugs.launchpad.net/bugs/1210748

Title:
  On Lenovo Thinkpad Twist internal mouse does not work after turning on
  machine, only works after reboot

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