I have the same issue and the trigger seemed to be moving from an AMD to
an Nvidia graphics card. Switching to console (CTRL Alt F1) and back
fixes it but can cause some issues with any graphical applications
running at the time. I am also using the Ubuntu automatic Nvidia driver
that appears to currently be one version behind the one on their
website.

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https://bugs.launchpad.net/bugs/1316873

Title:
  Left mouse button stops working

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