I followed advice from answers to the queston "How to enable natural scrolling with mouse in 17.04?", https://askubuntu.com/questions/904684 /how-to-enable-natural-scrolling-with-mouse-in-17-04.
In my case removing xserver-xorg-input-synaptics and restarting did the trick: sudo apt remove xserver-xorg-input-synaptics -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1706357 Title: Natural scrolling in Gnome Shell (17.10) doesn't appear to do anything To manage notifications about this bug go to: https://bugs.launchpad.net/ubuntu/+source/mousepad/+bug/1706357/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs