I can confirm that disabling LTO fixes the issue. Now I wonder if the
git-ubuntu import team will take the patch. I'm willing to submit it.
FWIW this is not a Debian Bullseye issue, I checked. python3-grpcio
1.30.2 is built against Python 3.9 there and it works just fine.

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https://bugs.launchpad.net/bugs/1971114

Title:
  Ubuntu 22.04 python3-grpcio causes some apps to use 100% of the CPU

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