>> Also, do these viruses ever use the SMTP server set up on that computer in
>> Outlook (via Windows registry), or do they always use external third-party
>> smtp servers for sending the spam?
>> 
>> (I'm researching this as a prerequisite to trying some additional anti-spam
>> strategies.)
 
>> always <<
I have seen some rubbish in german, a while ago, and seemingly built for the 
german infrastructure:
A high percentage of private internet access goes through a provider that does 
not authenticate
smtp, since they already have authenticated the connection.
The rubbish took advantage of that and was sending via the official mail server

A lot of other spam I receive is sent straight from the client's ip address to 
the target MX,
where outlook would - hopefully - send to the smarthost server first

Wolfgang



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