I know this is a shameless plug, but I'm a happy customer. Have Inter7 do a SugarBox install for less time/money than it takes to figure it out using online resources and googled howtos. I didn't have to second-guess or debug anything. Within 4 hours of the consultant logging in via SSH, I had SMTP-AUTH, POP-before-SMTP, SMTP/SSL, POP3, POP3/SSL, IMAP, IMAP/SSL, CRAM-MD5 and a complement of TinyDNS and SqWebMail all working together. Within another hour, he had MySQL replication and redundancy working. He left all the source code on my box so that I could make modifications and customizations later using "make install" and even build additional servers later.
If you don't make a living installing Qmail/Vpopmail servers, it's less expensive and more practical to just let someone else do it. I've installed qmail/vpopmail from scratch before and believe that it can be a PITA to get done right. -- Eric Ziegast