http://news.xinhuanet.com/english2010/health/2010-02/06/c_13165473.htm

      Agricultural chemical associated with birth defect  
     
      English.news.cn   2010-02-06 07:46:40  

LOS ANGELES, Feb. 5 (Xinhua) -- Exposure to agricultural chemical atrazine may 
raise the risk of birth defect called gastroschisis, U.S. researchers have 
found.

To find out a link between atrazine and gastroschisis, researchers at the 
University of Washington in Seattle analyzed 805 cases of live-born infants 
with gastroschisis between 1987 and 2006, along with 3,616 normal infants who 
acted as controls.

The researchers matched birth certificates with U.S. Geological Survey 
databases of agricultural spraying of atrazine, nitrates, and 
2,4-dichlorophenoxyacetic acid.

Gastroschisis occurred more often among infants born to mothers who lived less 
than 25 kilometers (or about 15.5 miles) from the site of high surface water 
contamination with atrazine. There was no increased risk associated with the 
other chemicals.

The study also found that the risk of gastroschisis was higher for women who 
conceived in the spring (March through May), when agricultural chemical use is 
more prevalent.

There is a body of evidence from the study that infant abdominal hernia rates 
are higher near farms using atrazine, the researchers noted.

Gastroschisis is an abdominal wall defect in which the intestines, and 
sometimes other organs, develop outside the abdomen through an opening in the 
abdominal wall. The incidence of this birth defect, also called infant 
abdominal hernia, has doubled to quadrupled over the past 30 years.

The study findings were presented on Friday to the annual meeting of the 
Society for Maternal-Fetal Medicine being held in Chicago.


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