You may want to have a look at Sahana Eden. It is open source.

They basically use the models to initialize everything and to load modules.
The modules can be "models" as in SQL tables or they can be code as
in (probably) "business objects".

Their software is used in a myriad of applications so it is structured to 
have 
a lot of settings, initialization and modules that a "normal" app would not 
need.


-- 
Resources:
- http://web2py.com
- http://web2py.com/book (Documentation)
- http://github.com/web2py/web2py (Source code)
- https://code.google.com/p/web2py/issues/list (Report Issues)
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