I am running web2py on Debian with nginx and the  uwsgi-plugin-python 
package. My configuration is similar to  yours, but uses mount instead of 
 app

<uwsgi>
  <plugin>python</plugin>
  <socket>127.0.0.1:9001</socket>
  <mount>/=/home/www-data/web2py/wsgihandler.py</mount>
</uwsgi>

Bill

On Friday, April 27, 2012 1:16:07 AM UTC-7, rif wrote:
>
> I had the same issue and I solved by adding plugin python in the uwsgi 
> web2py configuration:
>
> <uwsgi>
>     <plugin>python</plugin>                                               
>       <----------HERE------------
>     <socket>127.0.0.1:9001</socket>
>     <pythonpath>/home/www-data/web2py/</pythonpath>
>     <app mountpoint="/">
>         <script>wsgihandler</script>
>     </app>
> </uwsgi>
>
>>
>>  

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