Hello Ning--

> For refinement, I have two questions here need your help to figure out.
> 1.How to handle the only one tDB violation in my structure?
> There is only one violation left in my structure, this violation is
> located in transition region between helix and beta-strand, there
> were no any experimental restraints for this residue, and the tDB
> energy is about 4400 kcal/mol, the tDB energy is still about 4300
> kcal/mol even there is no tDB violations, would you please give me
> some suggestions how to figure out this problem? BTW, what is the
> acceptable number of tDB violations?

A single violation is certainly not usually seen to be a problem. Do
note that TorsionDB energies are relative only to other structure
calculations on the same protein, and the values do not go to
zero. One question is: is this TorsionDB violation seen in all
structures? 

All the same, to more strongly force the torsion atoms in the
transition region, a separate TorsionDB term could be created whose
selection is only the linker region- and this second term could be
given a larger energy scale value.

> 2. How to add chainID to pdb file?
> I have converted an ensemble of structure files to single pdb using
> ens2pdb, and I tried using wwPDB server to do structure validation,
> but failed. The errors show that there are missing chainID in this
> pdb. I tried using "-remaneSegid" to solve this problem, it didn't
> work. How can I add chainID? Could I get the pdb with chainID during
> refinement process? 
> 

This should do it:

  ens2pdb -renameSegid 'segid ""' A file*.pdb > toSubmit.pdb

Note that the first argument after -renameSegid is an atom selection.

best regards--
Charles

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