Hello Kevin--

> 
> thank you for your answer. With a .psf file I was able to get different 
> results for unlinked and linked isopeptide proteins.
> 
> The workflow now looks like this:
> 
> - Save a pdb and fix it with OpenMM's pdbfixer 
> https://github.com/openmm/pdbfixer
> - Use `pdb2psf` from XPLOR to create a psf file.
> - Manually (or programatically) add the Isopeptide bond between the correct 
> atoms.

There is an example of using a script for this in

  eginput/PSF_generation/isopeptide.py

in the Xplor-NIH distribution.

> - Instead of protocol.loadPDB() use protocol.initStruct(psf_file) ; 
> protocol.initCoords(pdb_file).
> 

Sounds like you got it!

Charles

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