Thanks Charles,

Indeed, I never made the switch from the old Xplor-NIH interface to the python 
interface.
I’ll follow your advice and see how I get on!

Best wishes,
Andrew

—
Andrew Atkinson, DPhil (Oxon.)
Integrative Biological NMR Group, IPBS, Toulouse
https://orcid.org/0000-0002-3645-9492
ResearcherID: ABE-8068-2020

[this email may reach you when you are not working - feel free to read, act on 
or respond at a time that suits you]

> On 27 Nov 2024, at 21:35, Charles Schwieters <[email protected]> wrote:
> 
> Hello Andrew--
> 
>> I'm trying to run a simulated annealing protocol using a VERY large
>> number of NOE (and non-NOE) restraints on my MacBook Pro. While
>> reading the restraints, I get an error message:
>> 
>> %ALLHP-err: too much memory requested.
>> Subroutine DIE called . Terminating
>> 
>> (which I've only found once in the archives of this list).
>> 
>> Is this likely to be machine dependent (RAM?) or am I reaching a
>> xplor-nih-dependent limit?  Advice welcome.
> 
> You do not report which version of Xplor-NIH you are running. The
> error message implies that you are running a script in the old XPLOR
> interface, which may well have some fixed size limitations. I suggest
> that you instead use the Python interface which has no such
> limitations. A good starting script might be
> gb1_simple/refine_nordc.py in the hands-on tutorial:
> 
>  https://bit.niddk.nih.gov/xplor-nih/xplor-nih-tutorial.tar.gz
> 
> Please let me know if you continue to have problems.
> 
> best regards--
> Charles
> 
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