Hello 정준--

First, the Fiber diffraction facility is only available via the old
XPLOR interface so you are currently stuck with its limitations, and
my lack of knowledge.

> 
> 1 Helix arrangement and NCS settings
>   My system contains a strongly crystalline 3/1 helix (three residues per
>   pitch), and unit-cell indexing has been determined as an orthorhombic cell
>   with parameters 23 Å, 10 Å, 8.26 Å, 90°, 90°, 90°. Within each cell, two
>   antiparallel helices are present. In the ncs strict protocol, only
>   translations along Z appear to be enforced. However, I would like to include
>   both helices in a single PDB file and simply replicate (extend) them along
>   the Z axis—without applying any additional rotations—since each residue is
>   already rotated by 120° in the input file. Which Xplor-NIH INP parameter(s)
>   should I use to achieve this “pure Z-axis expansion” of all helices in the
>   unit cell? Alternatively, is there a way within Xplor-NIH to translate the
>   helices along the X and Y axes and enforce their antiparallel symmetry prior
>   to performing fiber diffraction refinement?

If your PDB contains an entire unit cell's worth of atoms, then NCS
strict statements should not be necessary.

> 
> 2 Order of intensity data in the layer-line file
>   In a line such as
> 
> LAYER LINE   0   HIGHEST R   477   LOWEST R     1
> 
>   should the corresponding intensity values be listed in order from
>   highest R → lowest R, or from lowest R → highest R?

lowest to highest (from reading the source).

You might glean further insight by checking the test/fiber.inp and
test/fiber2.inp files in the Xplor-NIH distribution.

And do not hesitate to ask if you have further questions.

Charles

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