Apache is set to "MaxClients 50"
Zope.conf has set "zserver-threads 5" and <zodb_db main>
  cache-size 500
  pool-size 25
...
</zodb_db>

I will note that a cache-size of 500 is ridiculously low. (Even though old versions of Zope shipped configured like this!)

It needs to be at least 5000. Frankly, 50000 wouldn't be bad for a large, busy site.

To optimize your cache-size param, watch the ZODB read/write graph, and keep increasing the cache-size until (a) there's no more effect on reads or (b) you run into memory trouble.

Of course, the optimization will slip a little as site usage patterns change.

                --jcc
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Enfold Systems, LLC
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