Why do you have II=48 when ADDL=0 (no additional dose)?Should not be II=0? Serge Guzy
________________________________ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Yuyan Jin Sent: Tuesday, May 27, 2008 7:53 AM To: nmusers@globomaxnm.com Subject: [NMusers] multiple dose with unequal dosing intervals Hi All, I am trying to analyze a multiple dose oral PK data (with unequal dosing intervals) using NONMEM. second dose is given 48 hrs after the first dose and after that the drug is given on 12 hr dosing interval over 14 days. There are 8 sampling points available in first 48 h and then one trough sample is available after 7 days, and following last dose, 8 data points are available for next 24 h. the following is a representative of my data set #ID TIME DV AMT ADDL II MDV 102 0 0 60 0 48 1 102 0.5 205 0 0 0 0 102 1 305 0 0 0 0 102 2 283 0 0 0 0 102 4 134 0 0 0 0 102 6 78.8 0 0 0 0 102 8 51.5 0 0 0 0 102 12 17.6 0 0 0 0 102 24 2.16 0 0 0 0 102 48 0 60 30 12 1 102 192 704 0 0 0 0 102 360 585 0 0 0 0 102 360.5 782 0 0 0 0 102 361 1070 0 0 0 0 102 362 1460 0 0 0 0 102 364 1270 0 0 0 0 102 366 965 0 0 0 0 102 368 652 0 0 0 0 102 372 433 0 0 0 0 my model is not runing due to data record error message, Can anybody please help me setting up the data file? Any inputs will be appreciated. Thanks a lot, Yuyan graduate student -- The information contained in this email message may contain confidential or legally privileged information and is intended solely for the use of the named recipient(s). No confidentiality or privilege is waived or lost by any transmission error. If the reader of this message is not the intended recipient, please immediately delete the e-mail and all copies of it from your system, destroy any hard copies of it and notify the sender either by telephone or return e-mail. Any direct or indirect use, disclosure, distribution, printing, or copying of any part of this message is prohibited. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorized to state them to be the views of XOMA.
