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http://www.sunshine-project.org/publications/pr010702.html

The Sunshine Project
News Release
1 July 2002

Pentagon Program Promotes Psychopharmacological Warfare

In The Futurological Congress (1971), Polish writer Stanislaw Lem
portrayed a future in which disobedience is controlled with
hypothetical mind-altering chemicals dubbed "benignimizers". Lem's
fictional work opens with the frightening story of a police and
military biochemical attack on protesters outside of an international
scientific convention. As the environment becomes saturated with
hallucinogenic agents, in Lem's tale the protesters (and bystanders)
descend into chaos, overcome by delusions and feelings of complacency,
self-doubt, and even love.

If the Pentagon’s Joint Non-Lethal Weapons Directorate (JNLWD) has its
way, Lem may be remembered as a prophet.

(Austin and Hamburg, 1 July 2002) - The Advantages and Limitations of
Calmatives for Use as a Non-Lethal Technique, a 49 page report obtained
last week by the Sunshine Project under US information freedom law, has
revealed a shocking Pentagon program that is researching
psychopharmacological weapons. Based on "extensive review conducted on
the medical literature and new developments in the pharmaceutical
industry", the report concludes that "the development and use of
[psychopharmacological weapons] is achievable and desirable." These
mind-altering weapons violate international agreements on chemical and
biological warfare as well as human rights. Some of the techniques
discussed in the report have already been used by the US in the "War on
Terrorism".

  The team, which is based at the Applied Research Laboratory of
Pennsylvania State University, is assessing weaponization of a number
of psychiatric and anesthetic pharmaceuticals as well as "club drugs"
(such as the "date rape drug" GHB). According to the report, "the
choice administration route, whether application to drinking water,
topical administration to the skin, an aerosol spray inhalation route,
or a drug filled rubber bullet, among others, will depend on the
environment." The environments identified are specific military and
civil situations, including "hungry refugees that are excited over the
distribution of food", "a prison setting", an "agitated population" and
"hostage situations". At times, the JNLWD team's report veers very
close to defining dissent as a psychological disorder. 

  The drugs that Lem called "benignimizers" are called "calmatives" by
the military. Some calmatives were weaponized by the Cold War
adversaries, including BZ, described by those who have used it as "the
ultimate bad trip". Calmatives were supposed to have been deleted from
military stockpiles following the adoption of the Chemical Weapons
Convention in 1993, which bans any chemical weapon that can cause
death, temporary incapacitation, or permanent harm to humans or
animals.

  Calmative is military, not medical, terminology. In more familiar
medical language, most of the drugs under consideration are central
nervous system depressants. Most are synthetic, some are natural. They
include opiates (morphine-type drugs) and benzodiazpines, such as
Valium (diazepam). Antidepressants are also of great interest to the
research team, which is looking for drugs like Prozac (fluoxetine) and
Zoloft (sertraline) that are faster acting.

  Biochemicals and Treaties: Many of the proposed drugs can be
considered both chemical and biological weapons banned by the
Biological and Toxin Weapons Convention (BTWC), and the Chemical
Weapons Convention (CWC). As a practical matter, biological and
chemical "calmatives" must be addressed together. As the agents are
explicitly intended for military use, and are intended to incapacitate
their victims, they do not fall under the CWC's domestic riot control
agent exemption. Toxic products of living agents – such as the
neurotoxin botulinum – are considered both chemical and biological
agents. Any weapons use of neurotransmitters or substances mimicking
their action is similarly covered by both arms control treaties. The
researchers have developed a massive calmatives database and are
following biomedical research on mechanisms of drug addiction, pain
relief, and other areas of research on cognition-altering biochemicals.
For example, the JNLWD team is tracking research on cholecystokinin, a
neurotransmitter that causes panic attacks in healthy people and is
linked to psychiatric disorders. 

  Powerful Drugs: The drugs have hallucinogenic and other effects,
including apnea (stopped breathing), coma, and death. One class of
drugs under consideration are fentanyls. The report's cover features a
diagram of fentanyl. According to the US Drug Enforcement
Administration (DEA), the biological effects of fentanyls "are
indistinguishable from those of heroin, with the exception that the
fentanyls may be hundreds of times more potent." The report says that
the drugs’ profound effects may make it necessary to "check for the
occasional person who may stop breathing (many medical reasons in the
unhealthy, the elderly, and very young...", as well as victims who "'go
to sleep' in positions that obstruct their airway".

  Failed Drugs: The report also points out that pharmaceutical
candidates that fail because of excessive side-effects might be
desirable for use as weapons: ÒOften, an unwanted side-effect... will
terminate the development of a promising new pharmaceutical compound.
However, in the variety of situations in which non-lethal techniques
are used, there may be less need to be concerned with unattractive
side-effects... Perhaps, the ideal calmative has already been
synthesized and is awaiting renewed interest from its manufacturer.Ó

  Chemical Cocktails: As of March 2002, the team was researching a mix
of pepper spray ("OC") and an unidentified calmative agent. Pepper
spray is the most powerful chemical crowd control agent in use, and has
been associated with numerous deaths. Adding a pharmacological
"calmative" to OC would create a hideous concoction. The report
prioritizes Valium and Precedex (dexmeditomidine) for weaponization,
and it is possible that these are the agents that could be mixed with
OC. The researchers also suggest mixing ketamine with other drugs (see
below). The chemical cocktail proposals bear a resemblance to South
Africa's apartheid-era weapons research, whose director claimed under
oath to have attempted to develop a BZ and cocaine mixture for use on
government enemies.

  Torture: Precedex is sedative approved for use in the US on patients
hospitalized in intensive care units. The report draws attention to an
"interesting phenomenon" related to Precedex use - the drug increases
patients' reaction to electrical shock. The researchers suggest
sensitizing people by using Precedex on them, followed by use of
electromagnetic weapons to "address effects on the few individuals
where an average dose of the pharmacological agent did not have the
desired effect." Obviously, such a technique might be considered
torture, and certainly could be used to torture. To add to hypnotic and
delusional properties, the researchers suggest that
psychopharmaceutical agents could be designed to have physical effects
including headache and nausea, adding to their torture potential.
(Also, the report suggests that pharmaceutical drug candidates which
failed because of excessive side-effect might be okay to use as
weapons.)

  The researchers suggest that transdermal patches and transmucosal
(through mucous membranes) formulations of Buspar (buspirone) under
development by Bristol-Myers Squibb and TheraTech, Inc. "may be
effective in a prison setting where there may have been a recent
anxiety-provoking incident or confrontation." 

  Use in the War on Terrorism: Of course, uncooperative or rioting
prisoners would be extraordinarily unlikely to accept being drugged
with a transdermal patch or most conventional means. Any such
application of a "calmative" would likely be on individuals in shackles
or a straightjacket. The US has admitted that it forcibly sedates
Al-Qaida "detainees" held at the US base in Guantanamo, Cuba. Former
JNLWD commander and retired Col. Andy Mazzara, who directs the Penn
State team, says has he sent a "Science Advisor" to the US Navy to
assist the War on Terrorism.

  Modes of Delivery: A number of weaponization modes are discussed in
the report. These include aerosol sprays, microencapsulation, and
insidious methods such as introduction into potable water supplies and
psychoactive chewing gum. JNLWD is investing in the development of
microencapsulation technology, which involves creating granules of a
minute quantity of agent coated with a hardened shell. Distributed on
the ground, the shell breaks under foot and the agent is released. A
new mortar round being developed could deliver thousands of the minute
granules per round. The team concludes that new delivery methods under
development by the pharmaceutical industry will be of great weapons
value. These include new transdermal, transmucosal, and aerosol
delivery methods. The report cites the relevance of a lollipop
containing fentanyl used to treat children in severe pain, and notes
that "the development of new pain-relieving opiate drugs capable of
being administered via several routes is at the forefront of drug
discovery", concluding that new weapons could be developed from this
pharmaceutical research. 

  Dart Guns: The researchers express specific interest shooting humans
with guns loaded with carfentanil darts. Carfentanil is a veterinary
narcotic used to tranquilize large, dangerous animals such as bears and
tigers. Anyone who has watched wildlife shows on television is familiar
with the procedure. In the US, carfentanil is not approved for any use
on human beings. It is an abused drug and a controlled substance. Under
US law, first time offenders convicted of unlicensed possession of
carfentanil can be punished by up to 20 years in prison and a $1
million fine.

  Club Drugs: Most of the JNLWD team's weapon candidates are controlled
substances in most countries. Some are widely used legitimate
pharmaceuticals that are also drugs of abuse, such as Valium and
opiates. The Pentagon team advocates more research into the weapons
potential of convulsants (which provoke seizures) and “club drugs”, the
generally illegal substances used by some at "rave" and dance clubs.
Among those in the military spotlight are ketamine ("Special K"), GHB
(Gamma-hydroxybutrate, "liquid ecstasy"), and rohypnol ("Roofies"). The
latter two in particular are called "date rape drugs" because of
incidences of their use on victims of sexual and other crimes. Most are
DEA Schedule I or II narcotics that provoke hallucinations and can
carry a sentence of life imprisonment. For example, according to the
DEA, "Use of ketamine as a general anesthetic for humans has been
limited due to adverse effects including delirium and hallucinations...
Low doses produce vertigo, ataxia, slurred speech, slow reaction time,
and euphoria. Intermediate doses produce disorganized thinking, altered
body image, and a feeling of unreality with vivid visual
hallucinations. High doses produce analgesia, amnesia, and coma."

  Action: The Sunshine Project is calling for immediate termination of
this research and urges Parties to both the Chemical Weapons Convention
(CWC) and the Biological and Toxin Weapons Convention (BTWC) to quickly
condemn this research and to approve decisions reiterating the ban on
these weapons. For the CWC, opportunities to act will arise at the
Conference of the States Parties, to be held in The Hague beginning on
October 7th of this year, and the 1st Review Conference of the CWC, to
begin on April 28th 2003. For the BTWC, Parties should make proposals
at the 5th Review Conference, to begin in Geneva this November, and
place biological and toxin "calmatives" on the agenda of the next
Conference of States Parties or other multilateral group(s) created at
the Conference.

  This news release is a first report on this disturbing research
program. Additional information, on relationships between these weapons
and protection human rights, medical ethics, and drug research is
forthcoming. A summary of the report is available on the Sunshine
Project website (<http://www.sunshine-project.org>).

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