Meski dulu pernah kirimkan ttg nifural ini, tapi gak papa deh kirim lagi. Sebetulnya Nifural ini sekrg menjadi kontroversi & tidak direkomendasikan oleh dokter anak di US. Berdasarkan penelitian terakhir pada binatang percobaan rodentia (ex. tikus putih, dsb) ternyata menyebabkan mutasi gen & karsinogenik (penyebab kanker). Memang efek pada manusia belum ditemukan secara signifikan. Karenanya tidak disarankan menggunakan nifural. Sekrg pilihan tergantung di kita sb konsumen medis. Dokter boleh saja meresepkan berbagai obat, tapi pilihan untuk memakai / tidaknya suatuobat tetap ada di tangan kita kan.
Btw 80% lebih penyebab bayi diare adalah ROTAVIRUS. Obatnya hanya cairan dan waktu. Saya setuju dg yg dikatakan mbak dewi, konsep pemikiran kita yg harus diubah. Kalau anak sakit pertanyaannya bukan obatnya apa? tapi : perlu obatkah ? Dan cari sumber masalahnya ! cari penyebab diarenya. Saran saya sama spt e-mail saya sebelumnya. Kuncinya : perbanyak intake cairan, jaga jangan sampai dehidrasi, NO anti-diarrhea medicine dan tenang, pak. Saya tahu ini gak mudah seperti teorinya. Tapi percaya deh kita tetap harus rasional menghadapi berbagai kondisi terutama saat anak sakit. Saya gak tau pak nur pernah atau gak baca e-mail saya wkt sharing ttg pengalaman diare & muntah Alyssa. Waktu itu dia muntah lebih dari 10 x sehari plus diare >7 kali. Obatnya ? hanya waktu & cairan. Oralit / pedialit yg banyak, ASI, dsb. Kalau ya, semoga pengalaman itu juga bisa menjadi pelajaran. Yang penting semua tindakan pengobatan yg kita lakukan harus RASIONAL. Semoga Luthfi cepat sembuh. Lulu ---------------------------------------------------------------------------- Nifural (Nifuraxozide) derivat nitrofurantoin Carcinogenesis, Mutagenesis, and Impairment of Fertility: Nitrofurantoin presented evidence of carcinogenic activity in female B6C3F1 mice as shown by increased incidences of tubular adenomas, benign mixed tumors, and granulosa cell tumors of the ovary. In male F344/N rats, there were increased incidences of uncommon kidney tubular cell neoplasms, osteosarcomas of the bone, and neoplasms of the subcutaneous tissue. In one study involving subcutaneous administration of 75 mg/kg nitrofurantoin to pregnant female mice, lung papillary adenomas of unknown significance were observed in the F1 generation. Nitrofurantoin has been shown to induce point mutations in certain strains of Salmonella typhimurium and forward mutations in L5178Y mouse lymphoma cells. Nitrofurantoin induced increased numbers of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells but not in human cells in culture. Results of the sex-linked recessive lethal assay in Drosophila were negative after administration of nitrofurantoin by feeding or by injection. Nitrofurantoin did not induce heritable mutation in the rodent models examined. The significance of the carcinogenicity and mutagenicity findings relative to the therapeutic use of nitrofurantoin in humans is unknown. The administration of high doses of nitrofurantoin to rats causes temporary spermatogenic arrest; this is reversible on discontinuing the drug. Doses of 10 mg/kg/day or greater in healthy human males may, in certain unpredictable instances, produce a slight to moderate spermatogenic arrest with a decrease in sperm count. Pregnancy, Teratogenic Effects: Pregnancy Category B. Several reproduction studies have been performed in rabbits and rats at doses up to six times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to nitrofurantoin. In a single published study conducted in mice at 68 times the human dose (based on mg/kg administered to the dam), growth retardation and a low incidence of minor and common malformations were observed. However, at 25 times the human dose, fetal malformations were not observed; the relevance of these findings to humans is uncertain. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Non-teratogenic effects: Nitrofurantoin has been shown in one published transplacental carcinogenicity study to induce lung papillary adenomas in the F1 generation mice at doses 19 times the human dose on a mg/kg basis. The relationship of this finding to potential human carcinogenesis is presently unknown. Because of the uncertainty regarding the human implications of these animal data, this drug should be used during pregnancy only if clearly needed. --------------------------------------------------------------------- >> Kirim bunga, buket balon atau cake, klik,http://www.indokado.com/ >> Info balita, http://www.balita-anda.com >> Stop berlangganan, e-mail ke: [EMAIL PROTECTED]
