Meski dulu pernah kirimkan ttg nifural ini, tapi gak papa deh kirim lagi.
Sebetulnya Nifural ini sekrg menjadi kontroversi & tidak direkomendasikan
oleh dokter anak di US. Berdasarkan penelitian terakhir pada binatang
percobaan rodentia (ex. tikus putih, dsb) ternyata menyebabkan mutasi gen &
karsinogenik (penyebab kanker). Memang efek pada manusia belum ditemukan
secara signifikan. Karenanya tidak disarankan menggunakan nifural. Sekrg
pilihan tergantung di kita sb konsumen medis. Dokter boleh saja meresepkan
berbagai obat, tapi pilihan untuk memakai / tidaknya suatuobat tetap ada di
tangan kita kan.

Btw 80% lebih penyebab bayi diare adalah ROTAVIRUS.
Obatnya hanya cairan dan waktu.
Saya setuju dg yg dikatakan mbak dewi, konsep pemikiran kita yg harus
diubah.
Kalau anak sakit pertanyaannya bukan obatnya apa? tapi : perlu obatkah ?
Dan cari sumber masalahnya ! cari penyebab diarenya.

Saran saya sama spt e-mail saya sebelumnya. Kuncinya :
perbanyak intake cairan, jaga jangan sampai dehidrasi, NO anti-diarrhea
medicine dan tenang, pak.  Saya tahu ini gak mudah seperti teorinya. Tapi
percaya deh kita tetap harus rasional menghadapi berbagai kondisi terutama
saat anak sakit. Saya gak tau pak nur pernah atau gak baca e-mail saya wkt
sharing ttg pengalaman diare & muntah Alyssa.
Waktu itu dia muntah lebih dari 10 x sehari plus diare >7 kali. Obatnya ?
hanya waktu & cairan.
Oralit / pedialit yg banyak, ASI, dsb.
Kalau ya, semoga pengalaman itu juga bisa menjadi pelajaran. Yang penting
semua tindakan pengobatan yg kita lakukan harus RASIONAL.

Semoga Luthfi cepat sembuh.

Lulu
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Nifural (Nifuraxozide) derivat nitrofurantoin
Carcinogenesis, Mutagenesis, and Impairment of Fertility:

Nitrofurantoin presented evidence of carcinogenic activity in female B6C3F1
mice as shown by increased incidences of tubular adenomas, benign mixed
tumors, and granulosa cell tumors of the ovary. In male F344/N rats, there
were increased incidences of uncommon kidney tubular cell neoplasms,
osteosarcomas of the bone, and neoplasms of the subcutaneous tissue. In one
study involving subcutaneous administration of 75 mg/kg nitrofurantoin to
pregnant female mice, lung papillary adenomas of unknown significance were
observed in the F1 generation.

Nitrofurantoin has been shown to induce point mutations in certain strains
of Salmonella typhimurium and forward mutations in L5178Y mouse lymphoma
cells. Nitrofurantoin induced increased numbers of sister chromatid
exchanges and chromosomal aberrations in Chinese hamster ovary cells but not
in human cells in culture. Results of the sex-linked recessive lethal assay
in Drosophila were negative after administration of nitrofurantoin by
feeding or by injection. Nitrofurantoin did not induce heritable mutation in
the rodent models examined.

The significance of the carcinogenicity and mutagenicity findings relative
to the therapeutic use of nitrofurantoin in humans is unknown.

The administration of high doses of nitrofurantoin to rats causes temporary
spermatogenic arrest; this is reversible on discontinuing the drug. Doses of
10 mg/kg/day or greater in healthy human males may, in certain unpredictable
instances, produce a slight to moderate spermatogenic arrest with a decrease
in sperm count.

Pregnancy, Teratogenic Effects: Pregnancy Category B. Several reproduction
studies have been performed in rabbits and rats at doses up to six times the
human dose and have revealed no evidence of impaired fertility or harm to
the fetus due to nitrofurantoin. In a single published study conducted in
mice at 68 times the human dose (based on mg/kg administered to the dam),
growth retardation and a low incidence of minor and common malformations
were observed. However, at 25 times the human dose, fetal malformations were
not observed; the relevance of these findings to humans is uncertain. There
are, however, no adequate and well-controlled studies in pregnant women.
Because animal reproduction studies are not always predictive of human
response, this drug should be used during pregnancy only if clearly needed.

Non-teratogenic effects: Nitrofurantoin has been shown in one published
transplacental carcinogenicity study to induce lung papillary adenomas in
the F1 generation mice at doses 19 times the human dose on a mg/kg basis.
The relationship of this finding to potential human carcinogenesis is
presently unknown. Because of the uncertainty regarding the human
implications of these animal data, this drug should be used during pregnancy
only if clearly needed.






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