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  Water is Becoming a Dangerous Drug

  By Melissa Knopper


   Birth control pills, estrogen replacement drugs, ibuprofen, bug
spray,
   sunscreen, mouthwash and antibacterial soap: all of these products
could
   turn up in your next glass of tap water, according to the United
States
   Geological Survey (USGS). Last summer, USGS scientists sampled 139
rivers
   and streams, finding hundreds of prescription and over-the-counter
drugs
   and personal care products lingering in the nation's water supply.

   In many cases, these tiny drug particles were found in river water
that
   is recycled - flowing from one city's sewer plant into another city's

   drinking water system. Many cities can't afford the charcoal filters
   required to screen out the final traces of these byproducts, so they
end
   up in the drinking water, experts say. Rural homeowners who use well
   water are at an even greater risk. USGS researchers also turned up
   antibiotics in nearly half the streams that were sampled, raising
other
   concerns about the nation's growing antibiotic resistance problem.
"This
   study raised a bunch of red flags," says Dana Kolpin, lead author of
the
   USGS study. "At these low concentrations, I think there are going to
be
   long-term effects that may take several generations to show up."


   A Threat to Reproductive Health


   (Embedded image moved to file: pic05436.gif)he dangers of
   endocrine-disrupting water pollutants such as dioxin and
polychlorinated
   biphenyls (PCBs) are well known - they have been linked to a variety
of
   reproductive health problems, from endometriosis to low sperm counts.

   Synthetic hormones in the water may have similar health effects - on
both
   people and wildlife - at very low levels of exposure. "All of these
   compounds are going into a chemical soup," says Theo Colborn, senior
   scientist at the World Wildlife Fund (WWF) and author of "Our Stolen
   Future."


   Colborn says she is worried about pharmaceutical estrogens mixing
with
   chemicals already present in streams. "You can liken it to side
effects
   you get with a prescription drug - you don't know how it's going to
   interact with the over-the-counter drugs you're taking," Colborn
says.
   "It's the unexpected, interactive effects we never predicted that are
a
   real concern."


   For example, Colborn says, bisphenol A, a component of plastic that
is
   also used as a fire retardant, causes female mice to reach puberty
   earlier than normal. Bisphenol A forms a weak bond with the body's
   estrogen receptors. It can scramble a cell's natural communication
system
   and cause it to replicate too quickly. That, in turn, raises concerns

   about breast cancer in humans. What happens if this compound, which
is
   active at low levels of exposure, combines with estrogen from a birth

   control pill in the water? At this point, it's still unclear. Colborn

   says, "It could have long-term health effects."


   These estrogens also could have an additive effect with chemicals
such as
   PCBs, which are found in animal tissue. A recent study by researchers
at
   Michigan State University found mink that were fed a diet of
PCB-laden
   fish from the polluted Housatonic River in Connecticut had offspring
with
   lower birth weights and higher infant mortality rates. Housatonic
   Riverkeeper Tim Gray, a member of the New York-based Waterkeeper's
   Alliance, wonders if PCBs interfere with the mink's reproduction,
what
   will synthetic estrogen and other drugs do?


   Until recently, people thought the estrogens in birth control pills
were
   rendered inactive by the body because the kidneys tack on an extra
sugar
   molecule before they are excreted, says William Owens, a toxicologist
who
   researched estrogen patches for Procter & Gamble. But now, scientists

   have learned bacteria in sewage treatment plants chew off that sugar
   molecule.


   A British researcher, John Sumpter, contributed to this discovery
while
   studying fish living near a London wastewater treatment plant. He
found
   male fish that were producing eggs. After he found the compound
estradiol
   in the fish tissue, he concluded estrogens from birth control pills
were
   part of the problem.


   Antibiotic Resistance is Growing


   (Embedded image moved to file: pic32391.gif)nother active area of
   research and debate is antibiotic resistance. The Union of Concerned
   Scientists says farmers use 70 percent of antibiotics in the United
   States. Large factory farms use antibiotics to prevent confined,
   crowded-together cows or chickens from getting sick. But that
practice is
   creating "superbugs," such as virulent strains of salmonella that can
be
   deadly to humans and difficult to treat. Those superbugs typically
are
   spread to consumers through contaminated meat, but people who drink
from
   private wells also are vulnerable, says Dr. John Balbus, director of
the
   environmental health program for Environmental Defense.


   Meanwhile, thousands of pounds of triclosan - the active ingredient
in
   antibacterial soaps, deodorants, sponges and household cleaners - are

   also going down the drain into our waterways. Susan Cellura, a
   spokesperson for Ciba Specialty Chemicals, which manufactures
triclosan,
   says the chemical does not contribute to the antibacterial resistance

   problem. She quotes a recent report by the European Commission's
   Scientific Steering Committee, which concludes: "There is no
convincing
   evidence that triclosan poses a risk to humans or the environment by
   inducing or transmitting antibacterial resistance under current
   conditions of use." Ciba's research also purports to show that
triclosan
   does not pose any health threat to wildlife or humans because it's
   present in water at very low levels, 0.1 part per billion.


   "This is well below the 'safe' level of 0.7 parts per million
established
   by research," Cellura says. But other studies have shown that
triclosan
   does contribute to the resistance problem. Because triclosan is a
   broad-spectrum antimicrobial agent, it kills all bacteria on the body
and
   household surfaces - even the beneficial kind. That, in turn, creates
an
   environment where the superbugs can flourish, says a Tufts University

   study. The Tufts researchers also argue that the levels of triclosan
in
   common handsoaps and cleaners are not strong enough to kill certain
   harmful bacteria. In an August report, the American Medical
Association
   called on the scientific community to do a more thorough review of
   whether antibacterial consumer products do more harm than good. "The
use
   of these products have never been shown to be superior, to my
knowledge,
   to regular soap and water," says Dr. Tamar Barlan, director of the
Center
   for Science in the Public Interest's project on antibiotic
resistance.


   Protect Yourself - and the Environment


   (Embedded image moved to file: pic14604.gif)o what are the solutions?

   Legislation could be one option. The government could, for example,
   require all cities that use treated wastewater for drinking to
install
   charcoal filters, although that would be costly. That type of
legislation
   won't likely be passed until research pinpoints exactly how risky
these
   substances can be for humans and wildlife. But until recently, says
   Kolpin of the USGS, researchers had no way to even measure these
   compounds at the very low levels they appear in streams. The
Waterkeeper
   Alliance's Gray joins the WWF and other green groups in the call to
enact
   stronger clean water laws. "This new report paints a scary picture of

   what's out there in our rivers and lakes," he says.


   In the meantime, consumers can protect themselves and the
environment.
   WWF's Colborn recommends drinking distilled water, possibly produced
by
   your own distiller system. If you must buy bottled water, she adds,
pour
   it into a glass container instead of leaving it in the plastic
bottle.
   Other steps include:


   Use condoms instead of birth control pills; Choose natural menopause
   remedies instead of prescription hormone replacement therapy drugs;
   Return old prescriptions to the pharmacy rather than flushing them
down
   the toilet; Avoid unnecessary use of antibiotic drugs, and try plain
old
   soap and water unless your doctor recommends antibacterial soap for
   medical reasons; Switch to antibiotic-free meat or a vegetarian diet.



   Author's Note: For more information, contact: Campaign to End
Antibiotic
   Overuse, (202)572-3250; KeepAntibioticsWorking.com; The original USGS

   study; Our Stolen Future; Waterkeeper Alliance, (914)674-0622.
Melissa
   Knopper is a Denver-based science writer.
   ©Santa Fe New Mexican 2003

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