Here are is a link to information about your question, http://www.cvm.uiuc.edu/ceps/ivb/spay-neu.htm
We do our companion puppies at 8 weeks of age before they go to their new home. Ray & Pat Burgett Eaglecap Bernese Talee,Lexi,,Bell, Rider & Max www.goodbernerfood.com http://users.eoni.com/~eaglecap/ Draminski Ovulation Detector Rep