I am currently unable to install any Bioconductor 3.13 packages using 
BiocManager for Windows. Here is a sample R session using R 4.1.0beta for 
Windows. Notice the first time I type `install("Biobase")` there is no error 
message but the package is not installed. The second time and subsequent times 
I use install() I get an error message mentioning `readRDS`.

Any ideas?
Thanks
Gordon

> library(BiocManager)
Bioconductor version 3.13 (BiocManager 1.30.13), ?BiocManager::install for help
> install("Biobase")
Bioconductor version 3.13 (BiocManager 1.30.13), R 4.1.0 beta (2021-05-06 
r80268)
Installing package(s) 'BiocVersion', 'Biobase'
also installing the dependency ‘BiocGenerics’

> library(Biobase)
Error in library(Biobase) : there is no package called ‘Biobase’
> install("Biobase")
Bioconductor version 3.13 (BiocManager 1.30.13), R 4.1.0 beta (2021-05-06 
r80268)
Installing package(s) 'BiocVersion', 'Biobase'
also installing the dependency ‘BiocGenerics’

Error in readRDS(dest) : error reading from connection
> sessionInfo()
R version 4.1.0 beta (2021-05-06 r80268)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 18363)

Matrix products: default

locale:
[1] LC_COLLATE=English_Australia.1252  LC_CTYPE=English_Australia.1252
[3] LC_MONETARY=English_Australia.1252 LC_NUMERIC=C
[5] LC_TIME=English_Australia.1252

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base

other attached packages:
[1] BiocManager_1.30.13

loaded via a namespace (and not attached):
[1] compiler_4.1.0 tools_4.1.0

------------------------------------------
Professor Gordon K Smyth
Joint Head, Bioinformatics Division
Walter and Eliza Hall Institute of Medical Research

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