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The Page Laboratory at Brown University has openings for highly motivated post-docs in the field of structural biology using X-ray crystallography. Applicants with a strong background in biochemical techniques and structure determination are encouraged to apply. Prior experience with X-ray crystallography, molecular biology and protein expression and purification is preferred. The Page laboratory is housed in a new 105,000 sq. ft. research laboratory in Providence, RI. The laboratories are open-lab-space facilities and allow close interaction with the adjunct structural biology and molecular biology groups at Brown University (www.brown.edu/Research/Ship_Street/). At Brown University we have access to a new Rigaku/MSC Micromax-007 X-ray generator with an R-axis-IV++ detector. Finally, the Page laboratory is equipped with modern protein production and purification instrumentation. Providence, RI, is located on the coast between Boston (45 min.) and New York City (3 hours). Providence is still a rather affordable city with outstanding cultural, medical and educational institutions. Starting date, salary and project details are negotiable. The major research topics in the laboratory are the following: · Neuronal Scaffolding Proteins : In the dendritic spine, scaffolding proteins are responsible for linking the proteins at the cell membrane (ion channels and transmembrane receptors) to the proteins within the cell (phosphate signaling proteins and cytoskeletal proteins). Defects in the ability of scaffolding proteins form these macromolecular assemblies cause dramatic changes in neuronal structure and activity, resulting in defective neuronal signaling. · Phosphatase signaling in Neurons and T-cells: A second focus of the laboratory is to understand the details of phosphatase structure and signaling in immune and neuronal cells, so we can begin to understand the molecular details of the signaling events that control T-cell proliferation and neuronal signaling. For more details, please see the job announcement at www.brown.edu/mcb/rpage/employment.html Please send Cover Letter, CV and the names of three references to Rebecca Page, Brown University, Box G-E4, Providence, RI 02912. Alternatively, email the documents to [EMAIL PROTECTED] with "Post-Doctoral Position" in the subject line. Rebecca Rebecca Page Brown University Dept. of Molecular Biology, Cell Biology and Biochemistry Center of Genetics, Genomics and Proteomics Box G-E4 Providence, RI 02912 email: [EMAIL PROTECTED] ph: 401.863.6076 fx: 401.863.9653 http://www.brown.edu/mcb/rpage
