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Thanks all for your helpful replies.

I found the article mentioned very useful,

http://www.ccp4.ac.uk/newsletters/newsletter38/03_surfarea.html


My major problems started when I confused the 'contact area' with the
'area in contact' for a subunit in an oligomer, but now I understand
that areaimol doesn't compute that directly. It would be really nice if
the man page for areaimol pointed to the above article.

Cheers,
Dan.



[EMAIL PROTECTED] wrote:
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Hello,

I recently started using 'areaimol' in the CCP4 program suite,

CCP4 5.0
AREAIMOL 5.0
30/01/04

I am using default settings to look at 'simple area calculation' of a
protein.  The results file has two major sections,

1) ACCESSIBLE AREAS (for the residue/chain/oligomer)
2) CONTACT AREAS    (for the residue/chain/oligomer)

What is the difference between these two measures? (Are they even related
measures, or do they measure different physical properties of the
molecule?)

From the manual I read...

"The contact area is defined as the area on the Van der Waals surface of
an atom that can be contacted by a sphere of the given probe radius."

but that sounds just like the ASA?

I am a beginner with these concepts, so I don't see how (if at all) the
two measures are related, or why two measures are needed.

Thanks for any help,

Dan.





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