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Career Development Fellowship
The MRC Dunn Human Nutrition Unit (Director: Professor Sir John Walker)
wishes to appoint a Post-doctoral Scientist to undertake research into
the structure of bacterial respiratory complex I, as a member of Dr Leo
Sazanov’s group. You should have a PhD in a relevant subject and
preferably some experience in protein crystallisation, X-ray data
collection and model building/refinement.
Complex I of respiratory chains plays a central role in cellular energy
production and is implicated in human neurodegenerative diseases and
ageing. We have determined the first atomic structure of the catalytic
core of this large molecular machine (Sazanov, L.A. and Hinchliffe, P.
(2006) /Science/, *311*, 1430-1436; Hinchliffe, P. and Sazanov, L.A.
(2005) /Science/, *309*, 771-774). Our aims now are to determine the
structure of the catalytic domain in the presence of substrates, and to
solve the structure of the entire complex by X-ray crystallography.
This is a three-year training and development position for a
Post-doctoral Scientist who has recently completed their doctoral
studies, is moving into a new research discipline or has limited
previous experience of key transferable skills. The post provides
opportunities to develop research project skills and collaborative links
with colleagues within the Medical Research Council and elsewhere.
The work will be carried out at the Dunn Human Nutrition Unit, a
world-renowned centre for Bioenergetics research. A full job description
and additional information about the unit can be found at
_www.mrc-dunn.cam.ac.uk <http://www.mrc-dunn.cam.ac.uk/>_. Informal
enquiries may be addressed to Dr L.A. Sazanov by email:
[EMAIL PROTECTED] <mailto:[EMAIL PROTECTED]>
The starting salary will be in the range of £24,746 - £25,766 per annum,
depending upon qualifications and experience. This is supported by a
flexible pay and reward scheme, and optional MRC final salary pension
scheme.
*Applications should include a covering letter and full CV, with the
contact details of two professional referees who can be approached prior
to interview. Quoting job reference DHNU/406/6, please email your
application to: [EMAIL PROTECTED]
<mailto:[EMAIL PROTECTED]>** or post to: Recruitment Office,
Personnel Department, MRC Centre, Hills Road, Cambridge CB2 2QH.**
**Closing date: 25th May 2006***
--
Dr. Leonid A. Sazanov
Research group leader
Medical Research Council
Dunn Human Nutrition Unit
Wellcome Trust / MRC Building
Hills Road
Cambridge
CB2 2XY
WEB: www.mrc-dunn.cam.ac.uk
Tel: +44-1223-252910
Fax: +44-1223-252915
