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Dear All : Sorry for this non-CCP4 question. I am dealing with a protein binary complex, with known structure. We know that the interaction between both partners is processed via a short helix. OK, let's imagine that we would like to disrupt this interaction in vitro. I was thinking in using a peptide that will mimic the short helix of one of the partners to block the other one. Is it a crazy idea ?. Anyone has dealed with something like that with the same approach ?. Is it better to use peptides to disrupt protein complexes, or we could use small molecules as well ?. Any rational (but easy, for dummies level) approach to design the peptide that blocks the complex formation ?. I would appreciate some help and comments about that. Many, many thanks Cheers Francisco ----------------------------------------- Francisco J. Enguita, Ph.D. Host-pathogen Interactions Group Macromolecular Crystallography Laboratory ITQB EAN, Av. da República 2781-901 Oeiras Portugal Phone : +351-21-4469663 Fax : +351-21-4433644 E-mail : [EMAIL PROTECTED] -----------------------------------------
