I have a large molecule to refine.There are about three thousand residues in one asymmetric unit. Except for the lack of electron densities in several places, where the loops have been deleted, the rest parts fits well with density. But the R free and R work are all beyond 0.30 (R free = 0.35, R work = 0.30). I don't know how to reduce them. Can anyone give me some ideas?
Thank you!
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