Concanavalin A can be made to bind Zn and Ca. Its binding site has room for one transition metal and one alkaline earth metal.
http://www.jbc.org/cgi/content/abstract/271/27/16144 Highly recommended reading material on one of the classical protein targets Sumner's Nobel Prize lecture is here http://nobelprize.org/nobel_prizes/chemistry/laureates/1946/sumner-lecture.p df) Artem -----Original Message----- From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Neeraj Kapoor Sent: Thursday, June 12, 2008 11:15 PM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] Protein binding to Zn and Ca Hi all, I recently came across a question about an interesting idea. Does anyone know of an example of a protein binding to both Zn2+ and Ca2+ at the same time? Are there any known well studied precedents at all if any. Any help of insights would be very valuable. thanks, Neeraj
