Matrix Metallo Proteases (MMPs) have both Zn and Ca ions. In fact some, like MMP3, have two Zn atoms where one is structural and the other catalytic. All of the Ca ions seem to be structural.
Bobby Barnett ---- Original message ---- >Date: Fri, 13 Jun 2008 19:09:38 -0400 >From: Artem Evdokimov <[EMAIL PROTECTED]> >Subject: Re: [ccp4bb] Protein binding to Zn and Ca >To: CCP4BB@JISCMAIL.AC.UK > >Concanavalin A can be made to bind Zn and Ca. Its binding site has room for >one transition metal and one alkaline earth metal. > >http://www.jbc.org/cgi/content/abstract/271/27/16144 > >Highly recommended reading material on one of the classical protein targets > >Sumner's Nobel Prize lecture is here >http://nobelprize.org/nobel_prizes/chemistry/laureates/1946/sumner-lecture.p >df) > >Artem > >-----Original Message----- >From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Neeraj >Kapoor >Sent: Thursday, June 12, 2008 11:15 PM >To: CCP4BB@JISCMAIL.AC.UK >Subject: [ccp4bb] Protein binding to Zn and Ca > >Hi all, > I recently came across a question about an interesting idea. >Does anyone know of an example of a protein binding to both Zn2+ and >Ca2+ at the same time? Are there any known well studied precedents at >all if any. Any help of insights would be very valuable. > >thanks, >Neeraj Bobby L. Barnett PhD Department of Chemistry University of Cincinnati PO Box 210172 301 Clifton Court Cincinnati, OH 45221-0172 Phone:(513)556-9230 Lab:(513)556-9214 FAX:(513)556-9239
